Study note — Garcia et al. BJSM 2023 (non-occupational PA dose–response)

Shelf: Other studies we checked (candidate from prior pass — not Siim’s Zone 2 (R))
Full-text access: Yes — publisher PDF fetched 2026-09-18.
doi:10.1136/bjsports-2022-105669 · PMID 36854652
Labels: [Paper] · [Inference]

Citation

Garcia L, Pearce M, Abbas A, Mok A, Strain T, Ali S, Crippa A, Dempsey PC, Golubic R, Kelly P, Laird Y, McNamara E, Moore S, de Sa TH, Smith AD, Foster C, Johnson S, Linksted P, Brage S, Woodcock J, et al.
Non-occupational physical activity and risk of cardiovascular disease, cancer and mortality outcomes: a dose–response meta-analysis of large prospective studies.
Br J Sports Med. 2023;57(15):979–989.
doi:10.1136/bjsports-2022-105669

Methods [Paper]

• Systematic review + cohort-level dose–response meta-analysis.
• 196 articles; 94 cohorts; >30 million participants.
• Exposure harmonized as marginal MET-hours/week (mMET-h/week) of non-occupational activity (often MVPA combined), not a clean separate MPA-vs-VPA minute duel like Siim’s prose.

Key results (numbers) [Paper]

• Largest risk drops between 0 and 8.75 mMET-h/week (≈ recommended 150 min/week moderate-to-vigorous aerobic activity).
• Smaller marginal gains to 17.5 mMET-h/week; beyond that differences small/uncertain.
• At 8.75 mMET-h/week vs inactive: all-cause RR 0.69 (0.65–0.73); CVD mortality RR 0.71 (0.66–0.77); cancer mortality RR 0.85 (0.81–0.89).
• Population-impact estimates if inactive adults reached 8.75 mMET-h/week (e.g. ~15.7% of premature deaths averted in their framing).

Limitations / catch [Paper]

1. Observational cohorts; residual confounding.
2. Harmonization across heterogeneous PA instruments.
3. Not structured as Siim’s moderate-vs-vigorous high-volume duel (−17/−35, 200/800 min).

vs Siim’s use

Match to Siim claim: No (useful MVPA dose–response meta under Other studies, not his cite).

Paywall note

Full PDF retrieved from BJSM for this pass (open access article).